NLRP3 inflammasome mediates crystal-induced joint inflammation and dysfunction
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چکیده
منابع مشابه
The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance
nature medicine advance online publication Despite the absence of any overt infection or definitive evidence of autoantigen-mediated immune cell activation during obesity, chronic inflammation in this state is an established instigator of several diseases such as type 2 diabetes, defective immunity, atherosclerosis, certain cancers, central nervous system dysfunction and dementia1–4. Activation...
متن کامل[Crystal-induced joint inflammation].
The inflammatory response to microcrystals is one of the most powerful and intriguing examples of inflammation observable in man. Although many mechanisms of this reaction are well known, some aspects need to be further clarified, in particular those related to the self-limited nature of the process. Type and duration of the inflammatory reactions are mainly influenced by crystals characteristi...
متن کاملDDX19A Senses Viral RNA and Mediates NLRP3-Dependent Inflammasome Activation.
The NLRP3 inflammasome plays a major role in innate immune responses by activating caspase-1, resulting in secretion of IL-1β and inflammatory pathologic responses. Viral RNA can induce NLRP3 inflammasome activation. However, none of the components of NLRP3 inflammasome has the ability to bind viral RNA. Therefore, it had been proposed that there might have been some unidentified cytosolic RNA ...
متن کاملThe NLRP3 inflammasome promotes renal inflammation and contributes to CKD.
Inflammation significantly contributes to the progression of chronic kidney disease (CKD). Inflammasome-dependent cytokines, such as IL-1β and IL-18, play a role in CKD, but their regulation during renal injury is unknown. Here, we analyzed the processing of caspase-1, IL-1β, and IL-18 after unilateral ureteral obstruction (UUO) in mice, which suggested activation of the Nlrp3 inflammasome duri...
متن کاملMechanism of linezolid-induced NLRP3 inflammasome activation
Part of the Other Cell and Developmental Biology Commons Recommended Citation He, Qiong. "Mechanism of linezolid-induced NLRP3 inflammasome activation." MS
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ژورنال
عنوان ژورنال: Nature Reviews Rheumatology
سال: 2011
ISSN: 1759-4790,1759-4804
DOI: 10.1038/nrrheum.2011.164